Can I use Acetyl Tetrapeptide-2 with Niacinamide?
Works well together
Acetyl Tetrapeptide-2 and Niacinamide are generally compatible and can be layered in the same routine. As always, introduce one new active at a time and watch how your skin responds.
Acetyl Tetrapeptide-2Active
- ✓Signal peptide that upregulates elastin assembly proteins Fibulin-5 (FBLN5) and Lysyl Oxidase-Like 1 (LOXL1), restoring the cross-linking of tropoelastin into functional elastic fibers — the primary mechanism behind its anti-sagging and firming activity
- ✓Stimulates collagen type I, IV, VI, and XIV gene expression in fibroblasts, plus COL17A1 (collagen XVII) in keratinocytes for strengthened dermal-epidermal junction integrity
- ✓Increases keratinocyte and fibroblast adhesion to the ECM via focal adhesion pathway proteins (zyxin, integrin, talin), and inhibits MMPs that degrade collagen — providing structural density and resistance to gravity-related tissue laxity
NiacinamideActive
- ✓Reduces redness and blotchiness
- ✓Supports the skin barrier
- ✓Regulates oil
