Can I use Niacinamide with Piper Methysticum Root Extract?
Works well together
Niacinamide and Piper Methysticum Root Extract are generally compatible and can be layered in the same routine. As always, introduce one new active at a time and watch how your skin responds.
NiacinamideActive
- ✓Reduces redness and blotchiness
- ✓Supports the skin barrier
- ✓Regulates oil
Piper Methysticum Root ExtractSoothing
- ✓Helps reduce visible redness and irritation through kavalactones that modulate NF-κB and COX inflammatory pathways
- ✓Provides antioxidant protection via flavokawains and flavonoids (notably isosakuranetin) that scavenge reactive oxygen species
- ✓May offer a mild calming topical effect, relevant for sensitive, reactive, or post-procedure skin
- ⚠CIR Expert Panel (2009) concluded available data were insufficient to support safety in cosmetics due to uncharacterized dermal absorption of kavalactones, which have an established hepatotoxicity profile via oral intake
