Adapalene
A third-generation synthetic topical retinoid used as an OTC/prescription acne treatment that binds retinoic acid receptors to normalize skin cell turnover.
Also known as: adapalene usp, adapalene usp (retinoid) (acne treatment)
Benefits
- ✓Normalizes keratinocyte differentiation to reduce clogged pores
- ✓Reduces microcomedone formation
- ✓Anti-inflammatory action against acne-related inflammation
Watch for
- ⚠Can cause dryness, redness, and peeling especially when starting use
- ⚠Photosensitizing — sun protection advised
- ⚠Not for use during pregnancy without medical guidance
In depth
What it does
A third-generation synthetic topical retinoid used as an OTC/prescription acne treatment that binds retinoic acid receptors to normalize skin cell turnover. As an active ingredient, it is particularly valued for normalizes keratinocyte differentiation to reduce clogged pores, reduces microcomedone formation, and anti-inflammatory action against acne-related inflammation.
Skin type guide
Sensitive skin types should introduce this ingredient slowly and watch for any signs of irritation. Most other skin types tolerate it well.
How to use it
Apply after cleansing and any toning steps, before moisturiser. Start with a few times per week to assess tolerability before building to daily use.
Common questions
Is Adapalene safe to use during pregnancy?
Adapalene is generally not recommended during pregnancy. Retinoids in particular are associated with risks to fetal development and are typically advised against by dermatologists and OBs. Always check with your healthcare provider before using any active ingredient while pregnant.