SkinAtlas
Ingredient library / Hydroxypinacolone Retinoate
Active ingredient

Hydroxypinacolone Retinoate

Hydroxypinacolone Retinoate (HPR) is a synthetic ester of retinoic acid that binds retinoic acid receptors directly, offering retinoid activity with greater stability and lower irritation than retinol.

Also known as: HPR, Granactive Retinoid

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Benefits

  • ✓Synthetic ester of retinoic acid that binds retinoic acid receptors directly without requiring metabolic conversion
  • ✓Demonstrated greater stability and lower irritation potential than retinol in comparative studies
  • ✓Increases procollagen production in skin models

Watch for

  • ⚠Generally better tolerated than retinol or retinoic acid, but can still cause mild irritation, dryness, or increased photosensitivity in some users
  • ⚠Daytime sun protection recommended during use, as with other retinoids

In depth

What it does

Hydroxypinacolone Retinoate (HPR) is a synthetic ester of retinoic acid that binds retinoic acid receptors directly, offering retinoid activity with greater stability and lower irritation than retinol. As an active ingredient, it is particularly valued for synthetic ester of retinoic acid that binds retinoic acid receptors directly without requiring metabolic conversion, demonstrated greater stability and lower irritation potential than retinol in comparative studies, and increases procollagen production in skin models.

Skin type guide

Hydroxypinacolone Retinoate is a potent active that requires a careful introduction. Oily and combination skin types tend to tolerate it well; sensitive skin types should start with a lower frequency and patch test first.

How to use it

Use in your PM routine only — retinoids degrade in sunlight and increase photosensitivity. Start 1–2 nights per week, then increase frequency over several weeks as your skin adjusts. Always apply SPF the following morning.

At a glance
CategoryActive
IrritancyModerate–high
Beginner-friendlyUse care
Pregnancy safeNo
In your routine

Generally well-tolerated and easy to layer.

Found in 0 products

Common questions

Is Hydroxypinacolone Retinoate safe to use during pregnancy?

Hydroxypinacolone Retinoate is generally not recommended during pregnancy. Retinoids in particular are associated with risks to fetal development and are typically advised against by dermatologists and OBs. Always check with your healthcare provider before using any active ingredient while pregnant.