Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine
INCI: PALMITOYL DIPEPTIDE-5 DIAMINOBUTYROYL HYDROXYTHREONINE
One of the two active peptides in the Syn-Ake complex (Lipotec). Acts at the neuromuscular junction to reduce voluntary muscle contraction, contributing to visibly smoother expression lines over time.
Also known as: syn-ake dipeptide variant
Benefits
- ✓Mimics Waglerin-1 (temple viper venom peptide) to relax facial muscle micro-contractions
- ✓Reduces depth of expression lines
- ✓Studied in combination with its sister peptide for synergistic wrinkle-smoothing
Watch for
- ⚠Very low activity at typical use concentrations; meaningful effect requires sustained daily use
Compatibility
In depth
What it does
One of the two active peptides in the Syn-Ake complex (Lipotec). Acts at the neuromuscular junction to reduce voluntary muscle contraction, contributing to visibly smoother expression lines over time. As an active ingredient, it is particularly valued for mimics waglerin-1 (temple viper venom peptide) to relax facial muscle micro-contractions, reduces depth of expression lines, and studied in combination with its sister peptide for synergistic wrinkle-smoothing.
Skin type guide
Generally well-tolerated across skin types, including sensitive skin. As with any new ingredient, a patch test is always a sensible first step.
How to use it
Apply after cleansing and any toning steps, before moisturiser. Start with a few times per week to assess tolerability before building to daily use.
Common questions
What ingredients work well with Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine?
Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine pairs particularly well with Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Palmitoyl Tripeptide-1, and Niacinamide. These combinations are generally considered synergistic — they complement each other's effects without interfering or causing irritation.